The risk of severe outcomes following respiratory tract infections is significantly increased in
individuals over 60 years, especially in those with chronic medical conditions, ie …

Background Speech and language acquisition can be a challenge for young children with
Down syndrome (DS), and while early intervention is important, we do not know what early …

Aneuploidy syndromes impact multiple organ systems but understanding of tissue-specific
aneuploidy effects remains limited—especially for the comparison between peripheral …

Background: Down syndrome is the most frequent genetic cause of intellectual disability,
with an estimated birth prevalence of 14 per 10,000 live births. In Brazil, statistical data on …

Down syndrome (DS) is a chromosomal disorder associated with intellectual and physical
disabilities and has historically been viewed by health care providers through a negative …

Down syndrome (DS), also known as trisomy 21, is a genetic disorder caused by triplication
of Chromosome 21. Gene triplication may compromise different body functions but invariably …

Background Children with Down syndrome (DS) have a high risk of cardiac disease that
may prompt consideration for heart transplantation (HTx). However, transplantation in …

Few regular national clinical data are available for individuals with Down's syndrome (IDS)
bearing in mind that they are subject to countries variations in medical termination of …

Down syndrome (DS), a genetic pathology caused by triplication of chromosome 21, is
characterized by brain hypotrophy and impairment of cognition starting from infancy. While …

Summary Background People with Down syndrome suffer from multiple associated
diseases. However, knowledge on rates and causes of hospitalizations is limited. Methods …