During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

An astonishing number of extracellular matrix glycoproteins are expressed in dynamic
patterns in the developing and adult nervous system. Neural stem cells, neurons, and glia …

The correct positioning of neurons during development—achieved through directed
migration—is the basis for proper brain function. Several decades of research have yielded …

Apolipoprotein E (APOE) is a cholesterol transport protein and an isoform-specific major risk
factor for neurodegenerative diseases. The lipoprotein receptors that bind APOE have …

Neuronal migration is critical for establishing neocortical cell layers and migration defects
can cause neurological and psychiatric diseases. Recent studies show that radially …

Summary Apolipoprotein E receptor 2 (Apoer2), a member of the LDL receptor gene family,
and its ligand Reelin control neuronal migration during brain development. Apoer2 is also …

Reelin, a multifunctional extracellular protein that is important for mammalian brain
development and function, is secreted by different cell types in the prenatal or postnatal …

As the population ages, neurodegenerative diseases such as Alzheimer's disease (AD) are
becoming a significant burden on patients, their families, and health-care systems …

Reelin, a large protein that regulates neuronal migration during embryonic development,
activates a conserved signaling pathway that requires its receptors, very low-density …

Reelin is an extracellular matrix protein with various functions during development and in
the mature brain. It activates different signaling cascades in target cells, one of which is the …