The ketogenic diet (KD) is a high-fat, low-carbohydrate and adequate-protein diet that has
gained popularity in recent years in the context of neurological diseases (NDs). The …

Ketone bodies are metabolites that replace glucose as the main fuel of the brain in situations
of glucose scarcity, including prolonged fasting, extenuating exercise, or pathological …

Neuronal activity creates an intense energy demand that must be met by rapid metabolic
responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell …

The concept of the ischemic penumbra was originally defined as the area around a necrotic
stroke core and seen as the tissue at imminent risk of further damage. Today, the penumbra …

Diverse neurological disorders are associated with a deficit in brain energy metabolism,
often characterized by acute or chronic glucose hypometabolism. Ketones serve as the …

Epilepsy is a common neurological disease that is not always controlled, and the ketogenic
diet shows good antiepileptic effects drug-resistant epilepsy or seizures caused by specific …

Loss-of-function mutation of ABCC9, the gene encoding the SUR2 subunit of ATP sensitive-
potassium (KATP) channels, was recently associated with autosomal recessive ABCC9 …

Caspases are a family of cysteine proteases that predominantly cleave their substrates after
aspartic acid residues. Much of what we know of caspases emerged from investigation a …

Status epilepticus is a medical emergency with elevated morbidity and mortality rates, and
represents a leading cause of epilepsy-related deaths. Though status epilepticus can occur …

Glucose is the ultimate substrate for most brain activities that use carbon, including synthesis
of the neurotransmitters glutamate and γ-aminobutyric acid via mitochondrial tricarboxylic …