Drug discovery in tuberculosis. New drug targets and antimycobacterial agents

A Campaniço, R Moreira, F Lopes - European journal of medicinal …, 2018 - Elsevier
Tuberculosis (TB) remains a major health problem worldwide. The infectious agent,
Mycobacterium tuberculosis, has a unique ability to survive within the host, alternating …

Unpacking the Pathogen Box—an open source tool for fighting neglected tropical disease

CGL Veale - ChemMedChem, 2019 - Wiley Online Library
Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery

E Azzali, D Machado, A Kaushik… - Journal of medicinal …, 2017 - ACS Publications
Tuberculosis remains one of the deadliest infectious diseases in the world, and the
increased number of multidrug-resistant and extremely drug-resistant strains is a significant …

Mycobacterial tuberculosis enzyme targets and their inhibitors

AK Saxena, A Singh - Current Topics in Medicinal Chemistry, 2019 - ingentaconnect.com
Tuberculosis (TB) still continues to be a major killer disease worldwide. Unlike other bacteria
Mycobacterium tuberculosis (Mtb) has the ability to become dormant within the host and to …

Targeting DNA replication and repair for the development of novel therapeutics against tuberculosis

MA Reiche, DF Warner, V Mizrahi - Frontiers in molecular …, 2017 - frontiersin.org
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious
disease which results in approximately 10 million incident cases and 1.4 million deaths …

Multitargeting compounds: a promising strategy to overcome multi-drug resistant tuberculosis

G Stelitano, JC Sammartino, LR Chiarelli - Molecules, 2020 - mdpi.com
Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug
resistant M. tuberculosis strains, which lead to the need of new more efficient drugs. A …

Opportunities for overcoming tuberculosis: Emerging targets and their inhibitors

L Yang, X Hu, X Chai, Q Ye, J Pang, D Li, T Hou - Drug Discovery Today, 2022 - Elsevier
Tuberculosis (TB), an airborne infectious disease mainly caused by Mycobacterium
tuberculosis (Mtb), remains a leading cause of human morbidity and mortality worldwide …

Synthesis and biological evaluation of 2, 4, 5-trisubstituted thiazoles as antituberculosis agents effective against drug-resistant tuberculosis

UB Karale, VS Krishna, EV Krishna… - European journal of …, 2019 - Elsevier
The dormant and resistant form of Mycobacterium tuberculosis presents a challenge in
developing new anti-tubercular drugs. Herein, we report the synthesis and evaluation of …

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK

LR Chiarelli, G Mori, BS Orena, M Esposito, T Lane… - Scientific reports, 2018 - nature.com
Mycobacterium tuberculosis, the etiological agent of the infectious disease tuberculosis, kills
approximately 1.5 million people annually, while the spread of multidrug-resistant strains is …

Vitamin in the crosshairs: targeting pantothenate and coenzyme a biosynthesis for new antituberculosis agents

HS Butman, TJ Kotzé, CS Dowd… - Frontiers in Cellular and …, 2020 - frontiersin.org
Despite decades of dedicated research, there remains a dire need for new drugs against
tuberculosis (TB). Current therapies are generations old and problematic. Resistance to …