Vitamin C in stem cell biology: impact on extracellular matrix homeostasis and epigenetics

CD′ Aniello, F Cermola, EJ Patriarca… - Stem cells …, 2017 - Wiley Online Library
Transcription factors and signaling molecules are well‐known regulators of stem cell identity
and behavior; however, increasing evidence indicates that environmental cues contribute to …

Nutrients in the fate of pluripotent stem cells

V Lu, IJ Roy, MA Teitell - Cell metabolism, 2021 - cell.com
Pluripotent stem cells model certain features of early mammalian development ex vivo.
Medium-supplied nutrients can influence self-renewal, lineage specification, and earliest …

Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice

C Song, W Peng, S Yin, J Zhao, B Fu, J Zhang, T Mao… - Scientific reports, 2016 - nature.com
Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics

C Ding, H Li, Y Wang, F Wang, H Wu, R Chen… - Stem cell research & …, 2017 - Springer
Background Many reports have shown that various kinds of stem cells have the ability to
recover premature ovarian aging (POA) function. Transplantation of human amniotic …

Sodium fluoride induces nephrotoxicity via oxidative stress-regulated mitochondrial SIRT3 signaling pathway

C Song, B Fu, J Zhang, J Zhao, M Yuan, W Peng… - Scientific reports, 2017 - nature.com
Accumulation of mitochondrial reactive oxygen species (mROS) has been implicated in the
pathogenesis of fluorosis. As the main mitochondrial deacetylase, SIRT3 is closely …

Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1α signaling pathway

C Song, J Zhao, B Fu, D Li, T Mao, W Peng… - Free Radical Biology …, 2017 - Elsevier
Mitochondrial reactive oxygen species (ROS) production has been implicated in the
pathogenesis of fluoride toxicity in liver. Melatonin, an indolamine synthesized in the pineal …

[HTML][HTML] Vitamin C controls neuronal necroptosis under oxidative stress

L Ferrada, MJ Barahona, K Salazar, P Vandenabeele… - Redox biology, 2020 - Elsevier
Under physiological conditions, vitamin C is the main antioxidant found in the central
nervous system and is found in two states: reduced as ascorbic acid (AA) and oxidized as …

Signal inhibition reveals JAK/STAT3 pathway as critical for bovine inner cell mass development

F Meng, B Forrester-Gauntlett, P Turner… - Biology of …, 2015 - academic.oup.com
The inner cell mass (ICM) of mammalian blastocysts consists of pluripotent epiblast and
hypoblast lineages, which develop into embryonic and extraembryonic tissues, respectively …

Interleukin-6 stimulates in vitro development of late-stage ovine embryos

PK Javvaji, JR Francis, A Dhali, AP Kolte… - Journal of Reproductive …, 2023 - Elsevier
The effect of interleukin-6 (IL-6) supplementation during the different phases of in vitro
embryo culturing (IVC) on embryo development and embryonic gene expression was …

Reprogram or reboot: small molecule approaches for the production of induced pluripotent stem cells and direct cell reprogramming

DW Jung, WH Kim, DR Williams - ACS Chemical Biology, 2014 - ACS Publications
Stem cell transplantation is a potential therapy for regenerative medicine, which aims to
restore tissues damaged by trauma, aging, and diseases. Since its conception in the late …