The reversible histone acetylation and deacetylation are epigenetic phenomena that play
critical roles in the modulation of chromatin topology and the regulation of gene expression …

Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …

Helicobacter pylori infects the human stomach by escaping the host immune response. One
mechanism of bacterial survival and mucosal damage is induction of macrophage …

To determine the methylation profile of multiple tumor-related genes during multistep
hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes …

Tumor initiation and growth depend on its microenvironment in which cancer-associated
fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and …

Background: E-cadherin is an adhesion molecule involved in tumour invasion/metastasis.
Silencing of E-cadherin by promoter CpG methylation has been shown in both familial and …

The role of N6-methyladenosine (m6A) modification of host mRNA during bacterial infection
is unclear. Here, we show that Helicobacter pylori infection upregulates host m6A …

BACKGROUND & AIMS: Deregulation of forkhead box (Fox) proteins, an evolutionarily
conserved family of transcriptional regulators, leads to tumorigenesis. Little is known about …

Aberrant hypermethylation of promoter CpG islands is an important mechanism for the
inactivation of tumor suppressor genes. CpG island hypermethylation occurs in relation to …

To date, several reports have been published about CpG island methylation of various
genes in prostate cancer. However, most of these studies have focused on cancer tissue …