NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

The broad spectrum of human natural killer cell diversity

AG Freud, BL Mundy-Bosse, J Yu, MA Caligiuri - Immunity, 2017 - cell.com
Natural killer (NK) cells provide protection against infectious pathogens and cancer. For
decades it has been appreciated that two major NK cell subsets (CD56 bright and CD56 …

Natural killer cell education and the response to infection and cancer therapy: stay tuned

JE Boudreau, KC Hsu - Trends in immunology, 2018 - cell.com
The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …

Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways

MN Aydemir, HB Aydemir, EM Korkmaz, M Budak… - Gene Reports, 2021 - Elsevier
Recently an outbreak that emerged in Wuhan, China in December 2019, spread to the
whole world in a short time and killed> 1,410,000 people. It was determined that a new type …

Human natural killer cells: form, function, and development

EM Mace - Journal of Allergy and Clinical Immunology, 2023 - Elsevier
Human natural killer (NK) cells are innate lymphoid cells that mediate important effector
functions in the control of viral infection and malignancy. Their ability to distinguish" self" …

Natural killer cell recruitment to the lung during influenza A virus infection is dependent on CXCR3, CCR5, and virus exposure dose

LE Carlin, EA Hemann, ZR Zacharias… - Frontiers in …, 2018 - frontiersin.org
Natural killer (NK) cells are vital components of the antiviral immune response, but their
contributions in defense against influenza A virus (IAV) are not well understood. To better …

Immune surveillance of cytomegalovirus in tissues

A Mihalić, J Železnjak, B Lisnić, S Jonjić… - Cellular & Molecular …, 2024 - nature.com
Cytomegalovirus (CMV), a representative member of the Betaherpesvirinae subfamily of
herpesviruses, is common in the human population, but immunocompetent individuals are …

Innate immune responses in RNA viral infection

Q Xu, Y Tang, G Huang - Frontiers of medicine, 2021 - Springer
RNA viruses cause a multitude of human diseases, including several pandemic events in
the past century. Upon viral invasion, the innate immune system responds rapidly and plays …

The good and the bad of natural killer cells in virus control: perspective for anti-HBV therapy

P Fisicaro, M Rossi, A Vecchi, G Acerbi, V Barili… - International journal of …, 2019 - mdpi.com
Immune modulatory therapies are widely believed to represent potential therapeutic
strategies for chronic hepatitis B infection (CHB). Among the cellular targets for immune …

Recruited and tissue-resident natural killer cells in the lung during infection and cancer

M Franklin, E Connolly, T Hussell - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer (NK) cells are an important component of the innate immune system, and have
a key role in host defense against infection and in tumor surveillance. Tumors and viruses …