Regulatory T cells (Tregs) are important for the induction and maintenance of peripheral
tolerance therefore, they are key in preventing excessive immune responses and …

T cell reconstitution following lymphopenia from chemotherapy or stem cell transplant is
often slow and incompetent, contributing to the development of infectious diseases, relapse …

Adoptive immunotherapy with regulatory T cells (Tregs) is a promising treatment for allograft
rejection and graft-versus-host disease (GVHD). Emerging data indicate that, compared with …

Type 1 regulatory T (Tr1) cells are inducible, interleukin (IL)-10+ FOXP3− regulatory T cells
that can suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell …

Rheumatoid arthritis (RA) is an autoimmune disease that mainly affects the joints but also
leads to systemic inflammation. Auto-reactivity and dysregulation of self-tolerance are …

Solid organ transplantation remains the treatment of choice for end‐stage organ failure.
Whilst the short‐term outcomes post‐transplant have improved in the last decades, chronic …

Improper activation of the immune system contributes to a variety of clinical conditions,
including autoimmune and allergic diseases as well as solid organ and bone marrow …

The outcome of T-cell-mediated responses, immunity or tolerance, critically depends on the
balance of cytopathic versus regulatory T (T reg) cells. In the creation of stable tolerance to …

Endowed with the ability to actively suppress an immune response, regulatory T cells
(Tregs) hold the promise of halting ongoing pathogenic autoimmunity and restoring self …

Regulatory T cells (Tregs) maintain immune equilibrium by suppressing immune responses
through various multistep contact dependent and independent mechanisms. Cellular …