The study of homologous recombination has its historical roots in meiosis. In this context,
recombination occurs as a programmed event that culminates in the formation of crossovers …

DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …

Homologous recombination (HR) is an important mechanism for the repair of damaged
chromosomes, for preventing the demise of damaged replication forks, and for several other …

Meiotic recombination is carried out through a specialized pathway for the formation and
repair of DNA double-strand breaks made by the Spo11 protein, a relative of archaeal …

Five MutS homologs (MSH), which form three heterodimeric protein complexes, have been
identified in eukaryotes. While the human hMSH2-hMSH3 and hMSH2-hMSH6 …

Accurate segregation of homologous chromosomes during meiosis depends on the ability of
meiotic cells to promote reciprocal exchanges between parental DNA strands, known as …

In numerous species, the formation of meiotic crossovers is largely under the control of a
group of proteins known as ZMM. Here, we identified a new ZMM protein, HEI10, a RING …

Faithful segregation of homologous chromosomes (homologs) during meiosis depends on
chiasmata which correspond to crossovers between parental DNA strands. Crossover …

The synaptonemal complex (SC) is a proteinaceous complex that apparently mediates
synapsis between homologous chromosomes during meiotic prophase. In Saccharomyces …

Meiosis is a central feature of sexual reproduction. Studies in plants have made and
continue to make an important contribution to fundamental research aimed at the …