Recent developments in carbon-11 chemistry and applications for first-in-human PET studies
A Pees, M Chassé, A Lindberg, N Vasdev - Molecules, 2023 - mdpi.com
Positron emission tomography (PET) is a molecular imaging technique that makes use of
radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide …
radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide …
Emerging targets for positron emission tomography imaging in proteinopathies
M Chassé, N Vasdev - npj Imaging, 2024 - nature.com
Positron emission tomography (PET) imaging of neurodegenerative disease has historically
focused on a small number of established targets. The development of selective PET …
focused on a small number of established targets. The development of selective PET …
Preclinical evaluation of novel PET probes for dementia
R Cools, K Kerkhofs, RCF Leitao, G Bormans - Seminars in Nuclear …, 2023 - Elsevier
The development of novel PET imaging agents that selectively bind specific dementia-
related targets can contribute significantly to accurate, differential and early diagnosis of …
related targets can contribute significantly to accurate, differential and early diagnosis of …
Recent advancements in new tracers from first-in-human studies
Recent advancements in the development of positron emission tomography (PET) tracers
have significantly enhanced our ability to image neuroinflammatory processes and …
have significantly enhanced our ability to image neuroinflammatory processes and …
Positron emission tomography (PET) imaging biomarkers in Huntington's disease
L Everix, S Staelens, D Bertoglio - Biomarkers for Huntington's Disease …, 2023 - Springer
Huntington's disease (HD) is a rare, autosomal, and dominantly inherited
neurodegenerative disease characterized by aggregation of mutated Huntingtin protein …
neurodegenerative disease characterized by aggregation of mutated Huntingtin protein …
Neuroimaging to Facilitate Clinical Trials in Huntington's Disease: Current Opinion from the EHDN Imaging Working Group
NZ Hobbs, M Papoutsi, A Delva… - Journal of …, 2024 - content.iospress.com
Neuroimaging is increasingly being included in clinical trials of Huntington's disease (HD)
for a wide range of purposes from participant selection and safety monitoring, through to …
for a wide range of purposes from participant selection and safety monitoring, through to …
Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregates
Background Huntington's disease (HD) is a rare neurodegenerative disorder caused by an
expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant …
expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant …
PET Ligands for Imaging Mutant Huntingtin Aggregates: A Case Study in Non‐For‐Profit Scientific Management
CGF Dickmann, S Milicevic Sephton, RA Barker… - …, 2024 - Wiley Online Library
Positron emission tomography imaging of misfolded proteins with high‐affinity and selective
radioligands has played a vital role in expanding our knowledge of neurodegenerative …
radioligands has played a vital role in expanding our knowledge of neurodegenerative …
Assessment of dopaminergic pathways in Huntington's Disease: when, how, why? A (clinician-friendly) systematic review of the literature on PET and SPECT …
EKA Triumbari, DA Pizzuto, AR Bentivoglio… - Clinical and …, 2024 - Springer
Abstract Purpose Positron Emission Tomography (PET) and Single Photon Emission
Computerized Tomography (SPECT) allow the in-vivo evaluation of brain dopaminergic …
Computerized Tomography (SPECT) allow the in-vivo evaluation of brain dopaminergic …
靶向脑内异常蛋白聚集体的PET 显像剂研究进展
郭万通， 李钰莹， 崔孟超 - 药学进展, 2024 - pps.cpu.edu.cn
大多数神经退行性疾病被证实与脑内特定蛋白质的错误折叠与异常聚集有关, 如β-
淀粉样蛋白斑块和Tau 蛋白的异常聚集是阿尔茨海默病的两个重要病理学特征, α …
淀粉样蛋白斑块和Tau 蛋白的异常聚集是阿尔茨海默病的两个重要病理学特征, α …