Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although
originally implicated in the control of cytoskeletal events, it is currently known that these …

Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered
interactions with neighboring cells and the surrounding extracellular matrix, and enhanced …

Reactive oxygen species (ROS) act as intracellular compartmentalized second messengers,
mediating metabolic stress-adaptation. In skeletal muscle fibers, ROS have been suggested …

Abstract The Rho GTPase proteins Rac1, RhoA and Cdc42 have a central role in regulating
the actin cytoskeleton in dendritic spines, thereby exerting control over the structural and …

The adult mammalian intestine is composed of two connected structures, the absorptive villi
and the crypts, which house progenitor cells. Mouse crypts develop postnatally and are the …

The actin cytoskeleton–regulating GTPase Rac1 is required for insulin-stimulated GLUT4
translocation in cultured muscle cells. However, involvement of Rac1 and its downstream …

Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

In the past years, our view of the molecular and cellular mechanisms that ensure the self-
renewal of the skin has dramatically changed. Several populations of stem cells have been …

Podocytes are highly specialized epithelial cells with complex actin cytoskeletal architecture
crucial for maintenance of the glomerular filtration barrier. The mammalian Rho GTPases …

Desmosomes are patch-like intercellular adhering junctions (“maculae adherentes”), which,
in concert with the related adherens junctions, provide the mechanical strength to …