Energy substrate metabolism in cardiac hypertrophy

MF Allard - Current hypertension reports, 2004 - Springer
Cardiac hypertrophy is a response to long-term pathologic (eg, hypertension) or physiologic
(eg, exercise) hemodynamic overload accompanied by changes in energy substrate …

Molecular aspects of exercise-induced cardiac remodeling

BC Bernardo, JR McMullen - Cardiology clinics, 2016 - cardiology.theclinics.com
Cardiac remodeling is the result of molecular and cellular changes that manifest clinically as
changes in the size, shape, and function of the heart. In response to exercise training, all 4 …

Moderate endurance training prevents doxorubicin-induced in vivo mitochondriopathy and reduces the development of cardiac apoptosis

A Ascensão, J Magalhães… - American Journal …, 2005 - journals.physiology.org
The objective of this work was to test the hypothesis that endurance training may be
protective against in vivo doxorubicin (DOX)-induced cardiomyopathy through mitochondria …

Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart

DA Brown, KN Jew, GC Sparagna… - Journal of Applied …, 2003 - journals.physiology.org
The effect of endurance training on the resistance of the heart to left ventricular (LV)
functional deficit and infarction after a transient regional ischemia and subsequent …

Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat

DA Brown, AJ Chicco, KN Jew… - The Journal of …, 2005 - Wiley Online Library
This study was conducted to examine the role of myocardial ATP‐sensitive potassium
(KATP) channels in exercise‐induced protection from ischaemia–reperfusion (I–R) injury …

Regular exercise is associated with a protective metabolic phenotype in the rat heart

Y Burelle, RB Wambolt, M Grist… - American Journal …, 2004 - journals.physiology.org
Adaptation of myocardial energy substrate utilization may contribute to the cardioprotective
effects of regular exercise, a possibility supported by evidence showing that …

Cardiovascular responses to endurance training in children: effect of gender

P Obert, S Mandigouts, S Nottin, A Vinet… - European journal of …, 2003 - Wiley Online Library
Background The aim of the present study was to determine in healthy children the effect of a
well‐controlled endurance training programme on cardiac function at maximal exercise and …

Changes in the rat heart proteome induced by exercise training: Increased abundance of heat shock protein hsp20

MO Boluyt, JL Brevick, DS Rogers, MJ Randall… - …, 2006 - Wiley Online Library
Chronic exercise training elicits adaptations in the heart that improve pump function and
confer cardioprotection. To identify molecular mechanisms by which exercise training …

Exercise training induces respiratory substrate-specific decrease in Ca2+-induced permeability transition pore opening in heart mitochondria

M Marcil, K Bourduas, A Ascah… - American Journal of …, 2006 - journals.physiology.org
The purpose of this study was to determine whether regular exercise (treadmill running, 10
wk) alters the susceptibility of rat isolated heart mitochondria to Ca2+-induced permeability …

Exercise training differentially affects intrinsic excitability of autonomic and neuroendocrine neurons in the hypothalamic paraventricular nucleus

K Jackson, HMV Silva, W Zhang… - Journal of …, 2005 - journals.physiology.org
Oxytocinergic and vasopressinergic brain stem projections have been shown to play an
important role in mediating cardiovascular adjustments during exercise training (ET). The …