Abstract Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding
protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and …

Arsenic (As) contamination affects hundreds of millions of people globally. Although the
number of patients with chronic As exposure is large, the symptoms and long-term clinical …

As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or
mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress …

Increased exposure to environmental heavy metals and metalloids and their associated
toxicities has become a major threat to human health. Hence, the association of these …

Autophagy and apoptosis are two important catabolic processes contributing to the
maintenance of cellular and tissue homeostasis. Autophagy controls the turnover of protein …

Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …

Caspases are a family of cysteine proteases widely known as the principal mediators of the
apoptotic cell death response, but considerably less so as the contributors to the regulation …

Hydrogen peroxide is currently the most widely used apoptosis inducer due to its broad
cytotoxic efficacy against nearly all cell types. However, equivalent cytotoxicity is achieved …

Traumatic brain injury (TBI) is one of the significant causes of death and morbidity, and it is
hence a focus of translational research. Apoptosis plays an essential part in the …

Successful chemotherapeutic intervention for management of lung cancer requires an
efficient drug delivery system. Gold nanoparticles (GNPs) can incorporate various …