Gaucher disease provides a unique window into Parkinson disease pathogenesis

E Hertz, Y Chen, E Sidransky - Nature Reviews Neurology, 2024 - nature.com
An exciting development in the field of neurodegeneration is the association between the
rare monogenic disorder Gaucher disease and the common complex disorder Parkinson …

Beyond the lungs: exploring diverse applications of bromhexine and ambroxol

E Ahmadi, A Afrooghe, ZE Soltani, M Elahi, M Shayan… - Life Sciences, 2024 - Elsevier
The respiratory tract is commonly affected in multisystem disorders. Although many drugs
have been developed to target various components of these diseases, there is still a need …

Recognition and characterising non-motor profile in early onset Parkinson's disease (EOPD)

K Poplawska-Domaszewicz, MA Qamar… - Parkinsonism & Related …, 2024 - Elsevier
Early onset Parkinson's disease (EOPD) has been recently defined as a clinical entity with
subjects presenting with Parkinson's disease (PD) between the ages of 21-50 and replaces …

Midbrain organoids for Parkinson's disease (PD)-A powerful tool to understand the disease pathogenesis

HWS Babu, SM Kumar, H Kaur, M Iyer, B Vellingiri - Life Sciences, 2024 - Elsevier
Abstract Brain Organiods (BOs) are a promising technique for researching disease
progression in the human brain. These organoids, which are produced from human induced …

Genetic-based diagnostics of Parkinson's disease and other Parkinsonian syndromes

EN Somerville, Z Gan-Or - Expert Review of Molecular Diagnostics, 2024 - Taylor & Francis
Introduction Parkinson's disease (PD) is a complex disorder with vast clinical heterogeneity.
Recent genetic, imaging and clinical evidence suggest that there are multiple subtypes of …

[HTML][HTML] The Potential of Ambroxol as a Panacea for Neonatal Diseases: A Scoping Review

SY Al-Abdi, M Al-Aamri - Cureus, 2024 - pmc.ncbi.nlm.nih.gov
Ambroxol, a commonly used mucolytic agent, has been extensively studied for its clinical
effectiveness in managing respiratory conditions in pediatric and adult patients. The existing …

Severe GBA1 variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trials

E Menozzi, S Lucas Del Pozo, J Macnaughtan… - medRxiv, 2024 - medrxiv.org
Background Variants in the GBA1 gene are the commonest genetic risk factor for Parkinson
disease (PD). Genotype-phenotype correlations exist but with conflicting data, particularly in …