Considerable progress in our understanding of yeast genomes and their evolution has been
made over the last decade with the sequencing, analysis, and comparisons of numerous …

Proper regulation of ribosome biosynthesis is mandatory for cellular adaptation, growth and
proliferation. Ribosome biogenesis is the most energetically demanding cellular process …

Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with
high mortality. The absence of facile molecular genetics has been a major impediment to …

Genetic and biochemical analyses of RNA interference (RNAi) and microRNA (miRNA)
pathways have revealed proteins such as Argonaute and Dicer as essential cofactors that …

Even though the fungal kingdom contains more than 3 million species, little is known about
the biological roles of RNA silencing in fungi. The Colletotrichum genus comprises fungal …

RNase III is a global regulator of gene expression in Escherichia coli that is instrumental in
the maturation of ribosomal and other structural RNAs. We examine here how RNase III itself …

Abstract The RNase III enzymes Drosha and Dicer are essential for the production of small
non-coding RNAs (ncRNAs). In canonical RNAi, microRNAs (miRNAs) regulate gene …

In recent decades, RNA-based therapeutics have transitioned from a near impossibility to a
compelling treatment alternative for genetic disorders and infectious diseases. The mRNA …

In the opportunistic fungal pathogen Candida albicans both cellular morphology and the
capacity to cause disease are regulated by the transcriptional repressor Nrg1p. One of the …

The RNAi machinery is generally involved in genome protection in filamentous fungi;
however, the physiological role of RNAi has been poorly studied in fungal models. Here, we …