Hypersensitivity reactions to aspirin (acetylsalicylic acid) and other nonsteroidal anti‐
inflammatory drugs (NSAID s) constitute only a subset of all adverse reactions to these …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the leading cause of hypersensitivity
drug reactions. The different chemical structures, cyclooxygenase 1 (COX-1) and/or COX-2 …

Skin tests are of paramount importance for the evaluation of drug hypersensitivity reactions.
Drug skin tests are often not carried out because of lack of concise information on specific …

The literature on positive patch test results in drug reaction with eosinophilia and systemic
symptoms (DRESS) is reviewed. One hundred and five drugs were identified that have …

Delayed immune-mediated adverse drug reactions (IM-ADRs) are defined as reactions
occurring more than 6 hours after dosing. They include heterogeneous clinical phenotypes …

Clinically, erythema multiforme involves macular, papular or urticarial lesions, as well as the
classical iris or 'target lesions', distributed preferentially on the distal extremities. Lesions …

Allopurinol, a first-line drug for treating gout and hyperuricemia, is one of the leading causes
of severe cutaneous adverse reactions (SCARs). To investigate the molecular mechanism of …

Non‐steroidal anti‐inflammatory drugs (NSAID s) are the medications most frequently
involved in hypersensitivity drug reactions. Because NSAID s are prescribed for many …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the medicines most frequently
prescribed worldwide, many of which are available over the counter. 1 NSAIDs induce a …

BACKGROUND Due to possible serious adverse drug reactions (ADRs), the use of
metamizole for postoperative pain therapy in children is a subject of debate. Safety studies …