Alkylation reactions represent an important organic transformation to form C–C bonds. In
addition to conventional approaches with alkyl halides or sulfonates as alkylating agents …

Metal-catalyzed reductive coupling has emerged as an alternative to the use of
stoichiometric organometallic reagents in an increasingly diverse range of carbonyl and …

We report a mild, catalytic method for the intermolecular reductive coupling of feedstock
dienes and styrenes with ketones. Our conditions allow concomitant formation of a cobalt …

The rise of green chemistry has drawn attention to bond construction strategies that promote
atom economy and avoid mutagenic reagents. 1 For example, both goals are achieved by …

The chemistry of amines, amides, and other nitrogencontaining compounds plays a central
role in the organic synthesis. In fact, the first synthesized organic compound was urea. 1 The …

The addition of an organometallic reagent to a carbonyl compound or an imine represents
an important process in synthetic organic chemistry because in this reaction, together with a …

Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and
amines are of foundational importance to the practice of organic synthesis. After placing this …

A remaining challenge in the synthetic chemistry field is formation of all-carbon quaternary
centers, a feature found in many natural products, particularly in spirocycle systems. 1 …

Construction of new carbon–carbon bonds is the cornerstone of organic chemistry.
Organometallic reagents are amongst the most robust and versatile nucleophiles for this …

Enantioenriched alcohols found in an array of bioactive natural products and
pharmaceutical agents are often synthesized by asymmetric nucleophilic addition to …