Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
High-throughput methods in the discovery and study of biomaterials and materiobiology
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …
pivotal role in the development of novel implants, biomedical devices, and tissue …
3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling
Abstract 3D bioprinting is emerging as a promising technology for fabricating complex tissue
constructs with tailored biological components and mechanical properties. Recent advances …
constructs with tailored biological components and mechanical properties. Recent advances …
Human induced pluripotent stem cell–derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes
Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
Evolution of strategies to improve preclinical cardiac safety testing
G Gintant, PT Sager, N Stockbridge - Nature reviews Drug discovery, 2016 - nature.com
The early and efficient assessment of cardiac safety liabilities is essential to confidently
advance novel drug candidates. This article discusses evolving mechanistically based …
advance novel drug candidates. This article discusses evolving mechanistically based …
[HTML][HTML] Cardiovascular disease models: a game changing paradigm in drug discovery and screening
H Savoji, MH Mohammadi, N Rafatian, MK Toroghi… - Biomaterials, 2019 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …
drug discovery and development has been sky-rocketing, the number of approved drugs has …
[HTML][HTML] Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform
C Denning, V Borgdorff, J Crutchley, KSA Firth… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
[HTML][HTML] Cell maturation: Hallmarks, triggers, and manipulation
JR Alvarez-Dominguez, DA Melton - Cell, 2022 - cell.com
How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …
While maturity is usually deemed a terminal fate, it may be more helpful to consider …
Electrical and mechanical stimulation of cardiac cells and tissue constructs
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …
decades, highlighted by the development of human cell derived constructs that have shown …
Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem?
CC Veerman, G Kosmidis, CL Mummery… - Stem cells and …, 2015 - liebertpub.com
Cardiomyocytes from human pluripotent stem cells (hPSC-CMs) are increasingly used to
model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a …
model cardiac disease, test drug efficacy and for safety pharmacology. Nevertheless, a …