Natural products (NPs) are a rich source of structurally novel molecules, and the chemical
space they encompass is far from being fully explored. Over history, NPs have represented a …

Chitin, a polysaccharide with particular abundance in fungi, nematodes and arthropods is
immunogenic. It acts as a threat to other organisms, to tackle which they have been …

Tuberculosis is caused by Mycobacterium tuberculosis (MTB) and is the leading cause of
death from infectious diseases in the World. The search for new antituberculosis drugs is a …

Despite many methodological advances that have facilitated investigation of Mycobacterium
tuberculosis pathogenesis, analysis of essential gene function in this slow-growing …

Protein kinase G (PknG), a thioredoxin-fold–containing eukaryotic-like serine/threonine
protein kinase, is a virulence factor in Mycobacterium tuberculosis, required for inhibition of …

To effectively modulate the gene expression within an infected mammalian cell, the
pathogen Mycobacterium tuberculosis would need to bring about epigenetic modifications at …

Tuberculosis claims> 1 million lives annually, and its causative agent Mycobacterium
tuberculosis is a highly successful pathogen. Protein kinase B (PknB) is reported to be …

The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for
growth and have been proposed as possible drug targets. We used a titratable conditional …

All domains of life utilize protein phosphorylation as a mechanism of signal transduction. In
bacteria, protein phosphorylation was classically thought to be mediated exclusively by …

Virulence effectors secreted by Mycobacterium tuberculosis (Mtb) help subvert host immune
mechanisms and, therefore, are critical for establishing infection and pathogenesis …