Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a
pathological disorganized wound healing process with chronic inflammation. The TGF …

Erythroferrone (ERFE) is the main erythroid regulator of hepcidin, the homeostatic hormone
controlling plasma iron levels and total body iron. When the release of erythropoietin from …

Skeletal muscle plays a key role in postural retention as well as locomotion for maintaining
the physical activities of human life. Skeletal muscle has a second role as an elaborate …

Background Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease in developed and developing countries. The use of synbiotics has been proposed …

Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is
induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to …

As the largest endocrine organ, adipose tissue secretes many bioactive molecules that
circulate in blood, collectively termed adipokines. Efforts to identify such metabolic …

Over the past decades, there has been a major increase in type 2 diabetes (T2D)
prevalence in most regions of the world. Diabetic patients are more prone to cardiovascular …

Late-onset retinal degeneration (L-ORD) is an autosomal dominant disorder caused by a
missense substitution in CTRP5. Distinctive clinical features include sub-retinal pigment …