The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

Sodium glucose transporters (SGLTs) belong to the mammalian solute carrier family SLC5.
This family includes 12 different members in human that mediate the transport of sugars …

The Amino Acid–Polyamine-Organocation (APC) transporter GadC contributes to the
survival of pathogenic bacteria under extreme acid stress by exchanging extracellular …

Bacteria from the orders Bacillales and Clostridiales differentiate into stress-resistant spores
that can remain dormant for years, yet rapidly germinate upon nutrient sensing. How spores …

Abstract Transporters of the Nramp (Natural resistance-associated macrophage protein)
family import divalent transition metal ions into cells of most organisms. By supporting metal …

Found in all domains of life, transporters belonging to the LeuT-fold class mediate the import
and exchange of hydrophilic and charged compounds such as amino acids, metals, and …

Substrates of most transport proteins have not been identified, limiting our understanding of
their role in physiology and disease. Traditional identification methods use transport assays …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

Cell nutrition, detoxification, signalling, homeostasis and response to drugs, processes
related to cell growth, differentiation and survival are all mediated by plasma membrane …

NCS 1 proteins are H+/Na+ symporters specific for the uptake of purines, pyrimidines and
related metabolites. In this article, we study the origin, diversification and substrate specificity …