Role of the JNK pathway in human diseases
K Sabapathy - Progress in molecular biology and translational …, 2012 - Elsevier
The c-Jun-NH 2-terminal kinase (JNK) signaling pathway plays a critical role in regulating
cell fate, being implicated in a multitude of diseases ranging from cancer to neurological and …
cell fate, being implicated in a multitude of diseases ranging from cancer to neurological and …
HIV-1 Vpr—a still “enigmatic multitasker”
CA Guenzel, C Hérate, S Benichou - Frontiers in microbiology, 2014 - frontiersin.org
Like other HIV-1 auxiliary proteins, Vpr is conserved within all the human (HIV-1, HIV-2) and
simian (SIV) immunodeficiency viruses. However, Vpr and homologous HIV-2, and SIV Vpx …
simian (SIV) immunodeficiency viruses. However, Vpr and homologous HIV-2, and SIV Vpx …
Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts
hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) are cholesterol-lowering drugs
that exert other cellular effects and underlie their beneficial health effects, including those …
that exert other cellular effects and underlie their beneficial health effects, including those …
Inhibitors of c-Jun N-terminal kinases—JuNK no more?
MA Bogoyevitch, PG Arthur - Biochimica et Biophysica Acta (BBA)-Proteins …, 2008 - Elsevier
The c-Jun N-terminal kinases (JNKs) have been the subject of intense interest since their
discovery in the early 1990s. Major research programs have been directed to the screening …
discovery in the early 1990s. Major research programs have been directed to the screening …
HIV-1 Vpr: mechanisms of G2 arrest and apoptosis
JL Andersen, E Le Rouzic, V Planelles - Experimental and molecular …, 2008 - Elsevier
Since the first isolation of HIV-1 from a patient with generalized lymphadenopathy in 1983,
great progress has been made in understanding the viral life cycle and the functional …
great progress has been made in understanding the viral life cycle and the functional …
[HTML][HTML] The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza
B Sui, D Bamba, K Weng, H Ung, S Chang, J Van Dyke… - Virology, 2009 - Elsevier
Conventional approaches for therapeutic targeting of viral pathogens have consistently
faced obstacles arising from the development of resistant strains and a lack of broad …
faced obstacles arising from the development of resistant strains and a lack of broad …
The Progestin-Only Contraceptive Medroxyprogesterone Acetate, but Not Norethisterone Acetate, Enhances HIV-1 Vpr-Mediated Apoptosis in Human CD4+ T Cells …
M Tomasicchio, C Avenant, A Du Toit, RM Ray… - PloS one, 2013 - journals.plos.org
The glucocorticoid receptor (GR) regulates several physiological functions, including
immune function and apoptosis. The HIV-1 virus accessory protein, viral protein R (Vpr), can …
immune function and apoptosis. The HIV-1 virus accessory protein, viral protein R (Vpr), can …
HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells
A Snyder, ZC Alsauskas, JS Leventhal, PE Rosenstiel… - Aids, 2010 - journals.lww.com
Objective: HIV-associated nephropathy (HIVAN) is the most common cause of end-stage
renal disease in persons with HIV/AIDS and is characterized by focal glomerulosclerosis …
renal disease in persons with HIV/AIDS and is characterized by focal glomerulosclerosis …
Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses
W Nacken, C Ehrhardt, S Ludwig - Biological chemistry, 2012 - degruyter.com
C-Jun N-terminal kinases (JNK) are activated in course of many viral infections. Here we
analyzed the activity of JNK inhibitors on influenza A virus (IAV) amplification. Human lung …
analyzed the activity of JNK inhibitors on influenza A virus (IAV) amplification. Human lung …
Human immunodeficiency virus viral protein R as an extracellular protein in neuropathogenesis
A Ferrucci, MR Nonnemacher, B Wigdahl - Advances in virus research, 2011 - Elsevier
Numerous studies published in the past two decades have identified the viral protein R (Vpr)
as one of the most versatile proteins in the life cycle of human immunodeficiency virus type 1 …
as one of the most versatile proteins in the life cycle of human immunodeficiency virus type 1 …