Thirty years of the drug candidate NAMI‐A and the myths in the field of ruthenium anticancer compounds: a personal perspective

E Alessio - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …

Recent developments in ruthenium anticancer drugs

A Levina, A Mitra, PA Lay - Metallomics, 2009 - academic.oup.com
Interest in Ru anticancer drugs has been growing rapidly since NAMI-A ((ImH+)[RuIIICl4
(Im)(S-dmso)], where Im= imidazole and S-dmso= S-bound dimethylsulfoxide) or KP1019 …

Enhancing the activity of drugs by conjugation to organometallic fragments

P Chellan, PJ Sadler - Chemistry–A European Journal, 2020 - Wiley Online Library
Resistance to chemotherapy is a current clinical problem, especially in the treatment of
microbial infections and cancer. One strategy to overcome this is to make new derivatives of …

Metallotherapeutic complexes with high selective properties for anti-neoplastic therapy

S De, S Kazi, S Banerjee, S Banerjee, N Sarkar… - Coordination Chemistry …, 2024 - Elsevier
It is one of the challenging works to deal with second major cause of death due to cancer
and to reduce the mortality rate caused by this. Researchers have been finding various …

Ruthenium (II)/(III) DMSO-based complexes of 2-aminophenyl benzimidazole with in vitro and in vivo anticancer activity

SA Elsayed, S Harrypersad, HA Sahyon, MA El-Magd… - Molecules, 2020 - mdpi.com
New anticancer ruthenium (II/III) complexes [RuCl2 (DMSO) 2 (Hapbim)](1) and [RuCl3
(DMSO)(Hapbim)](2)(Hapbim= 2-aminophenyl benzimidazole) have been synthesized and …

Novel ternary Pd (II) complexes as potent anticancer drugs for ovarian carcinoma treatment

H Farhangian, AN Kharat - Journal of Molecular Structure, 2023 - Elsevier
A novel straightforward method has been introduced to synthesize two new water soluble Pd
complexes,[Pd (phd)(AA)] NO 3,(phd= 1, 10-phenanthroline-5, 6-dione; 1, AA= L-isoleucine …

Ru (DMSO) 4Cl2 nano-aggregated Nafion membrane modified electrode for simultaneous electrochemical detection of hypoxanthine, xanthine and uric acid

AS Kumar, P Swetha - Journal of Electroanalytical Chemistry, 2010 - Elsevier
Ru (DMSO) 4Cl2 is a good precursor complex in synthetic inorganic chemistry and also
considered to be an efficient anti-cancer drug. Here in, we are reporting∼ 80nm nano …

Am (m) ines make the difference: organoruthenium am (m) ine complexes and their chemistry in anticancer drug development

MV Babak, SM Meier, AA Legin… - … A European Journal, 2013 - Wiley Online Library
With the aim of systematically studying fundamental structure–activity relationships as a
basis for the development of RuII arene complexes (arene= p‐cymene or biphenyl) bearing …

Photochemical Reactivity of RuII6-p-cymene) Flavonolato Compounds

SL Saraf, TJ Fish, AD Benninghoff, AA Buelt… - …, 2014 - ACS Publications
Photoactivation is a promising approach for modulating the biological activity of RuII
compounds. In this work, RuII flavonolato compounds,[Ru (η6-p-cymene)(L)(3-Hfl)] OTf (8; 3 …

New half sandwich-type Ru (II) coordination compounds characterized by the fac-Ru (dmso-S) 3 fragment: influence of the face-capping group on the chemical …

I Bratsos, C Simonin, E Zangrando, T Gianferrara… - Dalton …, 2011 - pubs.rsc.org
The Ru (II) complex fac-[RuCl (dmso-S) 3 (dmso-O) 2][PF6](P2) was found to be an excellent
precursor for the facile preparation in high yield of half sandwich-type compounds of the …