RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

Recent advances suggest that the response of RNA metabolism to stress has an important
role in the pathophysiology of neurodegenerative diseases, particularly amyotrophic lateral …

Although it was long thought that eukaryotic translation almost always initiates at an AUG
start codon, recent advancements in ribosome footprint mapping have revealed that non …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

Regulation of mRNA translation, the process by which ribosomes decode mRNAs into
polypeptides, is used to tune cellular protein levels. Currently, methods for observing the …

The accumulation of stalled translation preinitiation complexes (PICs) mediates the
condensation of stress granules (SGs). Interactions between prion-related domains and …

Stress granules are condensates of non-translating mRNAs and proteins involved in the
stress response and neurodegenerative diseases. Stress granules form in part through …

Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

In eukaryotic cells, protein synthesis typically begins with the binding of eIF4F to the 7-
methylguanylate (m 7 G) cap found on the 5′ end of the majority of mRNAs. Surprisingly …

Preventing the immune escape of tumor cells by blocking inhibitory checkpoints, such as the
interaction between programmed death ligand-1 (PD-L1) and programmed death-1 (PD-1) …