Biochemistry, cell biology, and pathophysiology of the innate immune cGAS–cGAMP–STING pathway
In the decade since the discovery of the innate immune cyclic GMP–AMP synthase (cGAS)–
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …
Structure and function of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family: Tidying up diversity
Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1–7)
have been implicated in key biological and pathophysiological processes, including …
have been implicated in key biological and pathophysiological processes, including …
ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
JA Carozza, AF Cordova, JA Brown… - Proceedings of the …, 2022 - National Acad Sciences
The metazoan innate immune second messenger 2′ 3′-cGAMP is present both inside
and outside cells. However, only extracellular cGAMP can be negatively regulated by the …
and outside cells. However, only extracellular cGAMP can be negatively regulated by the …
Discovery of VH domains that allosterically inhibit ENPP1
PE Solomon, CJ Bracken, JA Carozza, H Wang… - Nature chemical …, 2024 - nature.com
Abstract Ectodomain phosphatase/phosphodiesterase-1 (ENPP1) is overexpressed on
cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular …
cancer cells and functions as an innate immune checkpoint by hydrolyzing extracellular …
Enzymes involved in metabolism of extracellular nucleotides and nucleosides: functional implications and measurement of activities
GG Yegutkin - Critical reviews in biochemistry and molecular …, 2014 - Taylor & Francis
Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all
organs and tissues. Most models of purinergic signaling depend on functional interactions …
organs and tissues. Most models of purinergic signaling depend on functional interactions …
History of ectonucleotidases and their role in purinergic signaling
H Zimmermann - Biochemical Pharmacology, 2021 - Elsevier
Ectonucleotidases are key for purinergic signaling. They control the duration of activity of
purinergic receptor agonists. At the same time, they produce hydrolysis products as …
purinergic receptor agonists. At the same time, they produce hydrolysis products as …
Structure-aided development of small-molecule inhibitors of ENPP1, the extracellular phosphodiesterase of the immunotransmitter cGAMP
Cancer cells initiate an innate immune response by synthesizing and exporting the small-
molecule immunotransmitter cGAMP, which activates the anti-cancer Stimulator of Interferon …
molecule immunotransmitter cGAMP, which activates the anti-cancer Stimulator of Interferon …
Autotaxin: structure-function and signaling
A Perrakis, WH Moolenaar - Journal of lipid research, 2014 - ASBMB
Autotaxin (ATX), or ecto-nucleotide pyrophosphatase/phosphodiesterase-2, is a secreted
lysophospholipase D (lysoPLD) that hydrolyzes extracellular lysophospholipids into the lipid …
lysophospholipase D (lysoPLD) that hydrolyzes extracellular lysophospholipids into the lipid …
Processing of protein ADP-ribosylation by Nudix hydrolases
ADP-ribosylation is a post-translational modification (PTM) of proteins found in organisms
from all kingdoms of life which regulates many important biological functions including DNA …
from all kingdoms of life which regulates many important biological functions including DNA …
Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis
B Srinivasan, M Baratashvili, M Van Der Zwaag… - Nature chemical …, 2015 - nature.com
The metabolic cofactor coenzyme A (CoA) gained renewed attention because of its roles in
neurodegeneration, protein acetylation, autophagy and signal transduction. The long …
neurodegeneration, protein acetylation, autophagy and signal transduction. The long …