Chromosome stability relies on an adequate length and complete replication of telomeres,
the physical ends of chromosomes. Telomeres are composed of short direct repeat DNA and …

Telomeric DNA sequences are difficult to replicate. Replication forks frequently pause or
stall at telomeres, which can lead to telomere truncation and dysfunction. In addition to being …

DNA double-strand break repair allows cells to survive both exogenous and endogenous
insults to the genome. In yeast, the recombinases Rad51 and Rad52 are central to multiple …

DNA inverted repeats (IRs) are widespread across many eukaryotic genomes. Their ability
to form stable hairpin/cruciform secondary structures is causative in triggering chromosome …

Break-induced replication (BIR) is a mechanism used to heal one-ended DNA double-strand
breaks, such as those formed at collapsed replication forks or eroded telomeres. Instead of …

DNA double-strand breaks (DSBs) and short telomeres are structurally similar, yet they have
diametrically opposed fates. Cells must repair DSBs while blocking the action of telomerase …

The human malaria parasite Plasmodium falciparum replicates within circulating red blood
cells, where it is subjected to conditions that frequently cause DNA damage. The repair of …

Telomeres protect chromosome ends and are distinguished from DNA double-strand breaks
(DSBs) by means of a specialized chromatin composed of DNA repeats bound by a …

Telomerase can generate a novel telomere at DNA double-strand breaks (DSBs), an event
called de novo telomere addition. How this activity is suppressed remains unclear …

DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to
maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a …