Enzymes synthesized by hyperthermophiles (bacteria and archaea with optimal growth
temperatures of> 80° C), also called hyperthermophilic enzymes, are typically thermostable …

The moderate stability of enzymes is one of the main drawbacks that hinder general
implementation of these interesting biocatalysts at industrial scale. An especially complex …

In biological systems, the amino acid cysteine combines catalytic activity with an extensive
redox chemistry and unique metal binding properties. The interdependency of these three …

This article will discuss the importance of specific extremophilic enzymes for applications in
industrial biotechnology. It will specifically address those enzymes that have applications in …

The molecular-replacement method has been extended to locate molecules and their
fragments in an electron-density map. The approach is based on a new spherically …

One of the first hurdles to be negotiated in the postgenomic era involves the description of
the entire protein content of the cell, the proteome. Such efforts are presently complicated by …

Atomistic resolution is the standard for high-resolution biomolecular structures, but
experimental structural data are often at lower resolution. Coarse-grained models are also …

Bacteriophage murein hydrolases exhibit high specificity towards the cell walls of their host
bacteria. This specificity is mostly provided by a structurally well defined cell wall-binding …

The 2.25 Å resolution crystal structure of a pol α family (family B) DNA polymerase from the
hyperthermophilic marine archaeon Thermococcus sp. 9° N-7 (9° N-7 pol) provides new …

The discovery of extremophiles has drastically changed our understanding towards the
diversity of life itself and the conditions under which it can be sustained. Extremophiles have …