Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Netrin-1 was the first axon guidance molecule to be discovered in vertebrates and has a
strong chemotropic function for axonal guidance, cell migration, morphogenesis and …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …

Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

Abstract The Hedgehog (Hh) pathway controls embryonic development and postnatal tissue
maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh ligands …

Neurotrophic factors are essential not only for guiding the organization of the developing
nervous system but also for supporting the survival and growth of neurons after traumatic …

Netrin-1 is a bifunctional chemotropic guidance cue that plays key roles in diverse cellular
processes including axon pathfinding, cell migration, adhesion, differentiation, and survival …

Brain malformations involving the corpus callosum are common in children with
developmental disabilities. We identified DCC mutations in four families and five sporadic …

Netrins, a family of laminin-related molecules, have been proposed to act as guidance cues
either during nervous system development or the establishment of the vascular system. This …