A synthetic lethal interaction occurs between two genes when the perturbation of either gene
alone is viable but the perturbation of both genes simultaneously results in the loss of …

Cancer is fundamentally a disease of the genome and inherited deficiencies in DNA repair
pathways are well established to increase lifetime cancer risk. Computational analysis of …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the curation and archival …

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view …

Combination of anti-cancer drugs is broadly seen as way to overcome the often-limited
efficacy of single agents. The design and testing of combinations are however very …

Abstract The Biological General Repository for Interaction Datasets (BioGRID:
https://thebiogrid. org) is an open access database dedicated to the annotation and archival …

We developed a systematic approach to map human genetic networks by combinatorial
CRISPR–Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all …

Combinatorial genetic screening using CRISPR–Cas9 is a useful approach to uncover
redundant genes and to explore complex gene networks. However, current methods suffer …

Identification of effective combination therapies is critical to address the emergence of drug-
resistant cancers, but direct screening of all possible drug combinations is infeasible. Here …

Cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), control the
transition between different phases of the cell cycle. CDK/cyclin activity is regulated by CDK …