The role of proteoglycans in cancer metastasis and circulating tumor cell analysis

TD Ahrens, SR Bang-Christensen… - Frontiers in cell and …, 2020 - frontiersin.org
Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw.
They represent not only the primary tumor site, but also potential metastatic lesions, and …

Microfluidics for liquid biopsies: recent advances, current challenges, and future directions

Y Belotti, CT Lim - Analytical chemistry, 2021 - ACS Publications
Liquid biopsy has seen tremendous progress over the past decade as it represents a
potential innovative solution to several limitations of current cancer management. By …

PD‐L1 expression on circulating tumor cells may be predictive of response to pembrolizumab in advanced melanoma: results from a pilot study

MA Khattak, A Reid, J Freeman, M Pereira… - The …, 2020 - academic.oup.com
Background PD‐1 inhibitors are routinely used for the treatment of advanced melanoma.
This study sought to determine whether PD‐L1 expression on circulating tumor cells (CTCs) …

Detection of clinical progression through plasma ctDNA in metastatic melanoma patients: a comparison to radiological progression

G Marsavela, AC McEvoy, MR Pereira, AL Reid… - British journal of …, 2022 - nature.com
Background The validity of circulating tumour DNA (ctDNA) as an indicator of disease
progression compared to medical imaging in patients with metastatic melanoma requires …

Detection and prognostic role of heterogeneous populations of melanoma circulating tumour cells

CA Aya-Bonilla, M Morici, X Hong, AC McEvoy… - British journal of …, 2020 - nature.com
Abstract Background Circulating tumour cells (CTCs) can be assessed through a minimally
invasive blood sample with potential utility as a predictive, prognostic and …

Genetic analysis of heterogeneous subsets of circulating tumour cells from high grade serous ovarian carcinoma patients

DB Asante, GRKA Mohan, E Acheampong, M Ziman… - Scientific Reports, 2023 - nature.com
Circulating tumour cells (CTCs) are heterogenous and contain genetic information from the
tumour of origin. They bear specific intra-and extra-cellular protein markers aiding in their …

MCAM/MUC18/CD146 as a multifaceted warning marker of melanoma progression in liquid biopsy

MC Rapanotti, E Cugini, M Nuccetelli… - International Journal of …, 2021 - mdpi.com
Human malignant melanoma shows a high rate of mortality after metastasization, and its
incidence is continuously rising worldwide. Several studies have suggested that …

Pre‐analytical factors affecting the establishment of a single tube assay for multiparameter liquid biopsy detection in melanoma patients

S Schneegans, L Lück, K Besler, L Bluhm… - Molecular …, 2020 - Wiley Online Library
The combination of liquid biomarkers from a single blood tube can provide more
comprehensive information on tumor development and progression in cancer patients …

Dual-procedural separation of CTCs in cutaneous melanoma provides useful information for both molecular diagnosis and prognosis

M Tucci, S D'Oronzo, F Mannavola… - Therapeutic …, 2020 - journals.sagepub.com
Background: Circulating tumor cells (CTCs) have recently emerged as a new dynamic
soluble marker for several malignancies including cutaneous melanoma (CM) and are …

A General Framework for Identifying Hierarchical Interactions and Its Application to Genomics Data

X Zhang, X Shi, Y Liu, X Liu, S Ma - Journal of Computational and …, 2023 - Taylor & Francis
The analysis of hierarchical interactions has long been a challenging problem due to the
large number of candidate main effects and interaction effects, and the need for …