Personalized cancer vaccines (PCVs) are reinvigorating vaccine strategies in cancer
immunotherapy. In contrast to adoptive T-cell therapy and checkpoint blockade, the PCV …

Extracellular vesicles (EVs) are secreted by both eukaryotes and prokaryotes, and are
present in all biological fluids of vertebrates, where they transfer DNA, RNA, proteins, lipids …

For cancer immunotherapy via tumor antigen vaccination in combination with an adjuvant,
major challenges include the identification of a particular tumor antigen and efficient delivery …

Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most
abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); …

Nanoscale objects, whether of biologic origin or synthetically created, are being developed
into devices for a variety of bionanotechnology diagnostic and pharmaceutical applications …

Traditional aluminum adjuvants can trigger strong humoral immunity but weak cellular
immunity, limiting their application in some vaccines. Currently, various immunomodulators …

Vaccination is the best way to prevent and reduce the damage caused by infectious
diseases in animals and humans. So, several vaccines are used for prophylactic purposes …

We have examined the neurotoxicity of aluminum in humans and animals under various
conditions, following different routes of administration, and provide an overview of the …

In 2011 a new syndrome termed 'ASIA Autoimmune/Inflammatory Syndrome Induced by
Adjuvants' was defined pointing to summarize for the first time the spectrum of immune …

Preclinical characterization of novel nanotechnology-based formulations is often challenged
by physicochemical characteristics, sterility/sterilization issues, safety and efficacy. Such …