Stroke remains a significant problem despite decades of work on neuroprotective strategies.
NMDA receptor (NMDAR) antagonists are neuroprotective in preclinical models, but have …

All-trans-retinoic acid (ATRA) and its synthetic analogues EC23 and EC19 direct cellular
differentiation by interacting as ligands for the retinoic acid receptor (RARα, β and γ) family …

Reengineering of cellular retinoic acid binding protein II (CRABPII) to be capable of binding
retinal as a protonated Schiff base is described. Through rational alterations of the binding …

Retinoids, such as all-trans-retinoic acid (ATRA), are endogenous signaling molecules
derived from vitamin A that influence a variety of cellular processes through mediation of …

A detailed understanding of the interactions between small-molecule ligands and their
proposed binding targets is of the utmost importance for modern drug-development …

The members of the rhodopsin family of proteins are involved in many essential light-
dependent processes in biology. Specific photoisomerization of the protein-bound …

Retinoids, such as all-trans-retinoic acid (ATRA), regulate cellular differentiation and
signalling pathways in chordates by binding to nuclear retinoic acid receptors (RARα/β/γ) …

A reengineered human cellular retinol binding protein II (hCRBPII), a 15‐kDa protein
belonging to the intracellular lipid binding protein (iLBP) family, generates a highly …

Rhodopsins are the sensor molecules responsible for visual perception in all sighted
organisms.[1] They all consist of a protein, opsin, bound to a retinoid polyene, most typically …

Mutants of cellular retinoic acid‐binding protein II (CRABPII), engineered to bind all‐trans‐
retinal as an iminium species, demonstrate photochromism upon irradiation with light at …