Disruption of small molecule transporter systems by Transporter‐Interfering Chemicals (TICs)

SCT Nicklisch, A Hamdoun - FEBS letters, 2020 - Wiley Online Library
Small molecule transporters (SMTs) in the ABC and SLC families are important players in
disposition of diverse endo‐and xenobiotics. Interactions of environmental chemicals with …

Generation of a homozygous mutant drug transporter (ABCB1) knockout line in the sea urchin Lytechinus pictus

H Vyas, CS Schrankel, JA Espinoza… - …, 2022 - journals.biologists.com
Sea urchins are premier model organisms for the study of early development. However, the
lengthy generation times of commonly used species have precluded application of stable …

The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new

L Stoeltje, JK Luc, T Haddad… - … Transactions of the …, 2024 - royalsocietypublishing.org
Commensal enteric bacteria have evolved systems that enable growth in the ecologic niche
of the host gastrointestinal tract. Animals evolved parallel mechanisms to survive the …

CRISPR/Cas9 mutagenesis reveals a role for ABCB1 in gut immune responses to Vibrio diazotrophicus in sea urchin larvae

TJ Fleming, CS Schrankel, H Vyas… - Journal of …, 2021 - journals.biologists.com
The ABC transporter ABCB1 plays an important role in the disposition of xenobiotics.
Embryos of most species express high levels of this transporter in early development as a …

Low levels of graphene and graphene oxide inhibit cellular xenobiotic defense system mediated by efflux transporters

S Liu, W Jiang, B Wu, J Yu, H Yu, XX Zhang… - …, 2016 - Taylor & Francis
Low levels of graphene and graphene oxide (GO) are considered to be environmentally
safe. In this study, we analyzed the potential effects of graphene and GO at relatively low …

A vesicular Na+/Ca2+ exchanger in coral calcifying cells

ME Barron, AB Thies, JA Espinoza, KL Barott… - PLoS …, 2018 - journals.plos.org
The calcium carbonate skeletons of corals provide the underlying structure of coral reefs;
however, the cellular mechanisms responsible for coral calcification remain poorly …

ABCC5 is required for cAMP-mediated hindgut invagination in sea urchin embryos

LE Shipp, RZ Hill, GW Moy, T Gökırmak… - …, 2015 - journals.biologists.com
ATP-binding cassette (ABC) transporters are evolutionarily conserved proteins that pump
diverse substrates across membranes. Many are known to efflux signaling molecules and …

Xenobiotic transporter activity in zebrafish embryo ionocytes

WE Gordon, JA Espinoza, DM Leerberg, D Yelon… - Aquatic toxicology, 2019 - Elsevier
Ionocytes are specialized cells in the epidermis of embryonic zebrafish (Danio rerio) that
play important roles in ion homeostasis and have functional similarities to mammalian renal …

Structural similarities between some common fluorophores used in biology, marketed drugs, endogenous metabolites, and natural products

S O'Hagan, DB Kell - Marine drugs, 2020 - mdpi.com
It is known that at least some fluorophores can act as 'surrogate'substrates for solute carriers
(SLCs) involved in pharmaceutical drug uptake, and this promiscuity is taken to reflect at …

Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares)

SCT Nicklisch, AK Pouv, SD Rees, AP McGrath… - … and Physiology Part C …, 2021 - Elsevier
Marine pollutants bioaccumulate at high trophic levels of marine food webs and are
transferred to humans through consumption of apex species. Yellowfin tuna (Thunnus …