Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …

Gene therapy, which involves replacement of a defective gene with a functional, healthy
copy of that gene, is a potentially beneficial cancer treatment approach particularly over …

Epithelial cell adhesion molecule (Ep-CAM; CD326) is used as a target by many
immunotherapeutic approaches, but little data are available about Ep-CAM expression in …

Background Human epithelial cell adhesion molecule (EpCAM) is overexpressed in many
cancers. Anti-EpCAM antibodies have shown promise in preclinical studies, but showed no …

A phase I clinical trial was conducted to determine the clinical safety of Telomelysin, a
human telomerase reverse transcriptase (hTERT) promoter driven modified oncolytic …

Previous studies in small series of patients with invasive breast cancer suggested a
prognostic value of Ep-CAM overexpression in primary tumor tissue. To corroborate these …

Gene therapy for the treatment of cancer was initiated with high levels of optimism and
enthusiasm. Recently, this perception has had to be tempered by the realisation that …

Purpose: A better understanding of the molecular pathways underlying the development of
epithelial ovarian cancer (EOC) is critical to identify ovarian tumor markers for use in …

Abstract The Na+/I− symporter (NIS) present in the membranes of thyroid cells is responsible
for the capacity of the thyroid to concentrate iodide. This allows treatment of thyroid cancers …

Recombinant adenovirus (rAd) and recombinant adeno-associated virus (rAAV) are among
the most extensively used vectors in gene therapy studies to date. These two vectors share …