Glia at Transition Zones

S Kucenas, P Pulh, P Topilko… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Neural cells are segregated into their distinct central nervous system (CNS) and peripheral
nervous system (PNS) domains. However, at specialized regions of the nervous system …

Self‐adaptive all‐in‐one delivery chip for rapid skin nerves regeneration by endogenous mesenchymal stem cells

LH Peng, XH Xu, YF Huang, XL Zhao… - Advanced Functional …, 2020 - Wiley Online Library
Skin wound therapy aims not only to restore skin protection but also to recover excitation
functions through nerve regeneration. During the restoration of skin nerves, the recruitment …

The embryonic zebrafish brain is seeded by a lymphatic-dependent population of mrc1+ microglia precursors

LA Green, MR O'Dea, CA Hoover, DF DeSantis… - Nature …, 2022 - nature.com
Microglia are the resident macrophages of the CNS that serve critical roles in brain
construction. Although human brains contain microglia by 4 weeks gestation, an …

Microglia cannibalism and efferocytosis leads to shorter lifespans of developmental microglia

H Gordon, ZT Schafer, CJ Smith - PLoS biology, 2024 - journals.plos.org
The overproduction of cells and subsequent production of debris is a universal principle of
neurodevelopment. Here, we show an additional feature of the developing nervous system …

Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

NL Kikel-Coury, JP Brandt, IA Correia, MR O'Dea… - PLoS …, 2021 - journals.plos.org
Glial cells are essential for functionality of the nervous system. Growing evidence
underscores the importance of astrocytes; however, analogous astroglia in peripheral …

Piezo1-mediated spontaneous calcium transients in satellite glia impact dorsal root ganglia development

JP Brandt, CJ Smith - Plos Biology, 2023 - journals.plos.org
Spontaneous Ca2+ transients of neural cells is a hallmark of the developing nervous
system. It is widely accepted that chemical signals, like neurotransmitters, contribute to …

Tetris in the nervous system: what principles of neuronal tiling can tell us about how glia play the game

DF DeSantis, CJ Smith - Frontiers in cellular neuroscience, 2021 - frontiersin.org
The precise organization and arrangement of neural cells is essential for nervous system
functionality. Cellular tiling is an evolutionarily conserved phenomenon that organizes …

Microglia exit the CNS in spinal root avulsion

LA Green, JC Nebiolo, CJ Smith - PLoS Biology, 2019 - journals.plos.org
Microglia are central nervous system (CNS)-resident cells. Their ability to migrate outside of
the CNS, however, is not understood. Using time-lapse imaging in an obstetrical brachial …

Pioneer axons employ Cajal's battering ram to enter the spinal cord

EL Nichols, CJ Smith - Nature communications, 2019 - nature.com
Sensory axons must traverse a spinal cord glia limitans to connect the brain with the
periphery. The fundamental mechanism of how these axons enter the spinal cord is still …

Huntingtin-associated protein 1 ameliorates neurological function rehabilitation by facilitating neurite elongation through TrKA-MAPK pathway in mice spinal cord …

L Miao, SW Qing, L Tao - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Aims Huntingtin-associated protein 1 (HAP1) is a neuronal protein closely associated with
microtubules and might facilitate neurological function rehabilitation. This study aimed to …