Cytokines are pleotrophic proteins that coordinate the host response to infection as well as
mediate normal, ongoing signaling between cells of nonimmune tissues, including the …

Inflammation is emerging as a critical mechanism underlying neurological disorders of
various etiologies, yet its role in altering brain function as a consequence of neuroinfectious …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …

Autism spectrum disorders (ASD) are neurodevelopmental diseases that affect an alarming
number of individuals. The etiological basis of ASD is unclear, and evidence suggests it …

Gene expression microarrays provide a powerful new tool for studying complex processes
such as brain aging. However, inferences from microarray data are often hindered by …

Cytokines and chemokines have been implicated in contributing to the initiation,
propagation and regulation of immune and inflammatory responses. Also, these soluble …

It is now clear that cytokines function as powerful regulators of glial cell function in the
central nervous system (CNS), either inhibiting or promoting their contribution to CNS …

In the decade following their initial discovery, the suppressor of cytokine signaling (SOCS)
proteins have been studied for their potential use as immunomodulators in disease. SOCS …

Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by
deficits in social interactions, communication, and increased stereotypical repetitive …

Proinflammatory cytokines, tumour necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin
(IL)-6, have multiple effects in the central nervous system (CNS) not strictly cytotoxic being …