The nucleoplasm is not homogenous; it consists of many types of nuclear bodies, also
known as nuclear domains or nuclear subcompartments. These self-organizing structures …

Abstract The multifunctional Survival Motor Neuron (SMN) protein is required for the survival
of all organisms of the animal kingdom. SMN impacts various aspects of RNA metabolism …

Many neurogenetic disorders are caused by the mutation of ubiquitously expressed genes.
One such disorder, spinal muscular atrophy, is caused by loss or mutation of the survival …

It is clear now that eukaryotic cells contain numerous membrane-less organelles, many of
which are formed in response to changes in the cellular environment. Being typically liquid …

Nm (2′-O-methylation) is one of the most common modifications in the RNA world. It has
the potential to influence the RNA molecules in multiple ways, such as structure, stability …

This review surveys what is known about the structure and function of the subnuclear
domains called Cajal bodies (CBs). The major focus is on CBs in mammalian cells but we …

Spinal muscular atrophy is a common, often lethal, neurodegenerative disease that results
from low levels of, or loss-of-function mutations in, the SMN (survival of motor neurons) …

The cell nucleus contains dozens of subcompartments that separate biochemical processes
into confined spaces. Cajal bodies (CBs) were discovered more than 100 years ago, but …

Spinal muscular atrophy (SMA) is a genetic disorder caused by mutations in the human
survival of motor neuron 1 gene, SMN1. SMN protein is part of a large complex that is …

Cajal bodies (CBs) are subnuclear domains implicated in small nuclear ribonucleoprotein
(snRNP) biogenesis. In most cell types, CBs coincide with nuclear gems, which contain the …