Bacterial antimicrobial resistance (AMR) is constantly evolving and horizontal gene transfer
through plasmids plays a major role. The identification of plasmid characteristics and their …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

Large-scale bacterial population genetics studies are now routine due to cost-effective
Illumina short-read sequencing. However, analysing plasmid content remains difficult due to …

Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) strains are a major
threat to global health. The development of effective control measures requires more …

Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …

Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in
both human and veterinary medicine. For several years now, colistin has been considered …

On 18 November 2015, Liu et al. reported the first description of plasmid-mediated colistin
resistance (mcr-1 gene) in food animals, food and humans in China [1]. In this issue …

Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

In this Leading article, we summarize current knowledge of the occurrence of the first and so
far only transferable colistin resistance gene, mcr-1. Its location on a conjugative plasmid is …