[HTML][HTML] Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

CV Breton, R Landon, LG Kahn, MB Enlow… - Communications …, 2021 - nature.com
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

Epigenetic and transgenerational reprogramming of brain development

TL Bale - Nature Reviews Neuroscience, 2015 - nature.com
Neurodevelopmental programming—the implementation of the genetic and epigenetic
blueprints that guide and coordinate normal brain development—requires tight regulation of …

[HTML][HTML] Epigenetic inheritance: concepts, mechanisms and perspectives

I Lacal, R Ventura - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Parents' stressful experiences can influence an offspring's vulnerability to many pathological
conditions, including psychopathologies, and their effects may even endure for several …

Stress-induced perinatal and transgenerational epigenetic programming of brain development and mental health

O Babenko, I Kovalchuk, GAS Metz - Neuroscience & Biobehavioral …, 2015 - Elsevier
Research efforts during the past decades have provided intriguing evidence suggesting that
stressful experiences during pregnancy exert long-term consequences on the future mental …

[HTML][HTML] RNA-mediated paternal heredity of diet-induced obesity and metabolic disorders

V Grandjean, S Fourré, DAF De Abreu, MA Derieppe… - Scientific reports, 2015 - nature.com
The paternal heredity of obesity and diabetes induced by a high-fat and/or high-sugar diet
(Western-like diet) has been demonstrated through epidemiological analysis of human …

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

SF Ng, RCY Lin, DR Laybutt, R Barres, JA Owens… - Nature, 2010 - nature.com
The global prevalence of obesity is increasing across most ages in both sexes. This is
contributing to the early emergence of type 2 diabetes and its related epidemic,. Having …

[HTML][HTML] Paternal diet defines offspring chromatin state and intergenerational obesity

A Öst, A Lempradl, E Casas, M Weigert, T Tiko… - Cell, 2014 - cell.com
The global rise in obesity has revitalized a search for genetic and epigenetic factors
underlying the disease. We present a Drosophila model of paternal-diet-induced …

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of …

T Fullston, EMCO Teague, NO Palmer… - The FASEB …, 2013 - Wiley Online Library
Obesity is highly prevalent, and its incidence is increasing. The previous study showing a
major effect of paternal obesity on metabolic health of offspring is confounded by …

Early life programming and neurodevelopmental disorders

TL Bale, TZ Baram, AS Brown, JM Goldstein, TR Insel… - Biological …, 2010 - Elsevier
For more than a century, clinical investigators have focused on early life as a source of adult
psychopathology. Early theories about psychic conflict and toxic parenting have been …

The consequences of early‐life adversity: neurobiological, behavioural and epigenetic adaptations

S Maccari, HJ Krugers… - Journal of …, 2014 - Wiley Online Library
During the perinatal period, the brain is particularly sensitive to remodelling by
environmental factors. Adverse early‐life experiences, such as stress exposure or …