Pharmacogenetics of breast cancer treatments: a sub-Saharan Africa perspective
KC Nthontho, AK Ndlovu, K Sharma… - Pharmacogenomics …, 2022 - Taylor & Francis
Breast cancer is the most frequent cause of cancer death in low-and middle-income
countries, in particular among sub-Saharan African women, where response to available …
countries, in particular among sub-Saharan African women, where response to available …
Association of CYP2B6 Genetic Variation with Efavirenz and Nevirapine Drug Resistance in HIV-1 Patients from Botswana
MJ Maseng, L Tawe, PK Thami, KK Seatla… - Pharmacogenomics …, 2021 - Taylor & Francis
Purpose CYP2B6 liver enzyme metabolizes the two non-nucleoside reverse transcriptase
inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) …
inhibitors Efavirenz (EFV) and Nevirapine (NVP) used in the antiretroviral therapy (ART) …
CYP2B6*6 Genotype Specific Differences in Artemether‐Lumefantrine Disposition in Healthy Volunteers
Abstract Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of the antimalarial
drugs artemether and lumefantrine. Here we investigated the effect of CYP2B6* 6 on the …
drugs artemether and lumefantrine. Here we investigated the effect of CYP2B6* 6 on the …
Genetic variability (785A> G, 516G> T and 64C> T) in the cyp2b6 gene among individuals in southwest Nigeria: implications for malaria treatment
OJ Bamikole, SA Ademola, D Agatha-Christie… - Human Gene, 2022 - Elsevier
Malaria remains a disease of major public health concern globally, with endemicity more
pronounced in the sub-Saharan Africa while children below the age of five alongside …
pronounced in the sub-Saharan Africa while children below the age of five alongside …
CASP9 genotype confers gentamicin susceptibility in intratympanic treatment of intractable vertigo caused by Ménière's disease
CJ Huang, TK Wan, TY Fang, PC Wang - Acta Oto-Laryngologica, 2019 - Taylor & Francis
Background: Ménière's disease (MD) is a disorder of the inner ear, causing episodes of
vertigo. Although surgery is reserved for intractable MD, intratympanic gentamicin (ITG) …
vertigo. Although surgery is reserved for intractable MD, intratympanic gentamicin (ITG) …
Distribution of alleles, genotypes and haplotypes of the CYP2B6 (rs3745274; rs2279343) and CYP3A4 (rs2740574) genes in the Malian population: Implication for …
Y Kassogue, B Diakite, O Kassogue, I Konate… - Medicine, 2021 - journals.lww.com
Cytochrome P450 enzymes play a central role in the phase I biotransformation process of a
wide range of compounds, including xenobiotics, drugs, hormones and vitamins. It is …
wide range of compounds, including xenobiotics, drugs, hormones and vitamins. It is …
Prevalence of Cytochrome P450 2B6 Single Nucleotide Polymorphism in an HIV-Positive Cohort in Jos, Nigeria: Implication for HIV Therapy
Background: Africans exhibit great diversity in cytochrome P450 2B6 isoenzyme (CYP2B6),
the major enzyme in efavirenz metabolism. Aim: We examined the frequency of two …
the major enzyme in efavirenz metabolism. Aim: We examined the frequency of two …
Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes
There is an increased recognition of the need to identify and quantify the impact of genetic
polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of …
polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of …
Trough plasma nevirapine levels, immunologic and virologic responses in composite CYP2B6*6/*18 HIV‐infected adult Nigerian patients
The influence of composite CYP2B6* 6/* 18 genotype on trough plasma nevirapine levels,
HIV RNA levels (virologic response) and CD4+ T lymphocyte and absolute lymphocyte …
HIV RNA levels (virologic response) and CD4+ T lymphocyte and absolute lymphocyte …