Web-based tools for computational enzyme design
Highlights•Enzymes are increasingly used in technological applications but often require
prior optimization.•Computational tools save time and effort in protein engineering …
prior optimization.•Computational tools save time and effort in protein engineering …
How can we discover developable antibody-based biotherapeutics?
Antibody-based biotherapeutics have emerged as a successful class of pharmaceuticals
despite significant challenges and risks to their discovery and development. This review …
despite significant challenges and risks to their discovery and development. This review …
Protein aggregation: in silico algorithms and applications
Protein aggregation is a topic of immense interest to the scientific community due to its role
in several neurodegenerative diseases/disorders and industrial importance. Several in silico …
in several neurodegenerative diseases/disorders and industrial importance. Several in silico …
Exploring the sequence features determining amyloidosis in human antibody light chains
The light chain (AL) amyloidosis is caused by the aggregation of light chain of antibodies
into amyloid fibrils. There are plenty of computational resources available for the prediction …
into amyloid fibrils. There are plenty of computational resources available for the prediction …
Revolutionizing enzyme engineering through artificial intelligence and machine learning
N Singh, S Malik, A Gupta… - Emerging Topics in Life …, 2021 - portlandpress.com
The combinatorial space of an enzyme sequence has astronomical possibilities and
exploring it with contemporary experimental techniques is arduous and often ineffective …
exploring it with contemporary experimental techniques is arduous and often ineffective …
Machine learning approaches in diagnosis, prognosis and treatment selection of cardiac amyloidosis
Cardiac amyloidosis is an uncommon restrictive cardiomyopathy featuring an unregulated
amyloid protein deposition that impairs organic function. Early cardiac amyloidosis …
amyloid protein deposition that impairs organic function. Early cardiac amyloidosis …
CPAD 2.0: a repository of curated experimental data on aggregating proteins and peptides
Abstract The Curated Protein Aggregation Database (CPAD) is a manually curated and
open-access database dedicated to providing comprehensive information related to …
open-access database dedicated to providing comprehensive information related to …
Understanding the mutational frequency in SARS-CoV-2 proteome using structural features
The prolonged transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) virus in the human population has led to demographic divergence and the …
CoV-2) virus in the human population has led to demographic divergence and the …
[HTML][HTML] Protein Condensates and Protein Aggregates: In Vitro, in the Cell, and In Silico
K Venko, E Žerovnik - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
Similar to other polypeptides and electrolytes, proteins undergo phase transitions, obeying
physicochemical laws. They can undergo liquid-to-gel and liquid-to-liquid phase transitions …
physicochemical laws. They can undergo liquid-to-gel and liquid-to-liquid phase transitions …
MPTherm-pred: analysis and prediction of thermal stability changes upon mutations in transmembrane proteins
The stability of membrane proteins differs from globular proteins due to the presence of
nonpolar membrane-spanning regions. Using a dataset of 929 membrane protein mutations …
nonpolar membrane-spanning regions. Using a dataset of 929 membrane protein mutations …