Chronic cough is globally prevalent across all age groups. This disorder is challenging to
treat because many pulmonary and extrapulmonary conditions can present with chronic …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Despite substantial efforts dedicated to the development of new, nonaddictive analgesics,
success in treating pain has been limited. Clinically available analgesic agents generally …

The long history of local anesthetics (LAs) starts out in the late 19th century when the content
of coca plant leaves was discovered to alleviate pain. Soon after, cocaine was established …

Microglia, resident immune cells in the central nervous system, play a role in
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …

Nociceptors, the high-threshold primary sensory neurons that trigger pain, interact with
immune cells in the periphery to modulate innate immune responses. Whether they also …

Neuronal electrochemical signals involve the flux of sodium ions through voltage-gated
sodium channels (Na V) located in the neurolemma. Of the nine sodium channel subtypes …

Cough medicines have been in use for over a century to treat the common and troublesome,
but often helpful, symptoms of cough in children. They contain various combinations of “anti …

Influenza A virus (IAV) is a common respiratory pathogen and a global cause of significant
and often severe morbidity. Although inflammatory immune responses to IAV infections are …

The immune and nervous systems have co-evolved complex mechanisms to sense
environmental dangers and orchestrate a concerted response to safeguard tissue and …