Artemisia Argyi essential oil ameliorates acetaminophen-induced hepatotoxicity via CYP2E1 and γ-glutamyl cycle reprogramming

W Cui, Q Cao, L Liu, X Yin, X Wang, Y Zhao, Y Wang… - Phytomedicine, 2024 - Elsevier
Background The hepatotoxicity induced by acetaminophen (APAP), a commonly used
antipyretic, analgesic and anti-inflammatory drug in clinical practice, has received …

PI3K inhibitor “alpelisib” alleviates methotrexate induced liver injury in mice and potentiates its cytotoxic effect against MDA-MB-231 triple negative breast cancer cell …

RM Gamal, SH Hazem, MF Hamed… - Toxicology and Applied …, 2024 - Elsevier
Hepatotoxicity is the main off-target effect of methotrexate (MTX) limiting its effective clinical
use. Besides, MDA-MB231 breast cancer cells show chemoresistance, partly via PI3K/AKT …