Cancer progression often benefits from the selective conditions present in the tumour
microenvironment, such as the presence of cancer-associated fibroblasts (CAFs) …

Insufficient tissue oxygenation, or hypoxia, contributes to tumor aggressiveness and has a
profound impact on clinical outcomes in cancer patients. At decreased oxygen tensions …

Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a pivotal
factor of the tumor (patho-) physiome since it can promote tumor progression and resistance …

Human breast tumors contain regions of hypoxia in which cells that are located far from a
functional blood vessel have significantly reduced oxygen concentrations when compared …

A lot of effort has been done to study how cancer cells react to low-oxygen tension, a
condition known as hypoxia. Indeed, abnormal and dysfunctional blood vessels in the tumor …

Lymphatic dissemination from the primary tumor is a major mechanism by which breast
cancer cells access the systemic circulation, resulting in distant metastasis and mortality …

The microenvironment of solid tumors is a heterogeneous, complex milieu for tumor growth
and survival that includes features such as acidic pH, low nutrient levels, elevated interstitial …

Hypoxia is a common feature of the tumor microenvironment, which is characterized by
tissue oxygen deficiency due to an aggressive proliferation of cancer cells. Hypoxia …

Interactions between cancer cells and stromal cells, including blood vessel endothelial cells
(BECs), lymphatic vessel endothelial cells (LECs), bone marrow-derived angiogenic cells …

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects
ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and …