Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects multiple
organ systems due to an inactivating variant in either TSC1 or TSC2, resulting in the …

Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

Neural stem/progenitor cell (NSPC) proliferation and self‐renewal, as well as insult‐induced
differentiation, decrease markedly with age. The molecular mechanisms responsible for …

The restoration of myelin sheaths on demyelinated axons remains a major obstacle in the
treatment of multiple sclerosis (MS). Currently approved therapies work by modulating the …

Myelin is the lipid-rich structure formed by oligodendrocytes (OLs) that wraps the axons in
multilayered sheaths, assuring protection, efficient saltatory signal conduction and metabolic …

Prior studies support a role for mammalian target of rapamycin (mTOR) signaling in
oligodendrocyte differentiation and myelination. Here we use Cre-recombinase driven by …

The mammalian target of rapamycin (mTOR) pathway integrates multiple signals and
regulates crucial cell functions via the molecular complexes mTORC1 and mTORC2. These …

During CNS development, oligodendrocytes, the myelinating glia of the CNS, progress
through multiple transitory stages before terminating into fully mature cells. Oligodendrocyte …

Preterm birth is an evolving challenge in neonatal health care. Despite declining mortality
rates among extremely premature neonates, morbidity rates remain very high. Currently …

The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates
environmental information regarding energy availability and stimulates anabolic molecular …