Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are
expressed by T cells and various other immune and non-immune cell types are central to T …

Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF)
ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion …

The costimulatory effects of CD27 on T lymphocyte effector function and memory formation
has been confined to evaluations in mouse models, in vitro human cell culture systems, and …

In vitro work has defined the TNF receptor family member CD27 as a T and B cell co-
stimulatory molecule. Its activity is governed by the transient availability of its TNF-like ligand …

Organ transplantation appears today to be the best alternative to replace the loss of vital
organs induced by various diseases. Transplants can, however, also be rejected by the …

Interferon (IFN)-γ, a cytokine critical for resistance to infection and tumors, is produced by
CD4+ helper T lymphocytes after stimulation by cultured dendritic cells (DCs) that secrete a …

Transplantation of organs between genetically different individuals of the same species
causes a T cell–mediated immune response that, if left unchecked, results in rejection and …

In 2013, cancer immunotherapy was named 'breakthrough of the year'based on the outcome
of clinical trials with blocking antibodies to the T-cell co-inhibitory receptors CTLA-4 and PD …

We describe the molecular and cellular mechanisms believed to be responsible for the
rejection of renal allografts, including acute T cell–mediated rejection, acute antibody …

Regulatory T cells (Tregs) are critical mediators of immune homeostasis. The co-stimulatory
molecule CD27 is a marker of highly suppressive Tregs, although the role of the CD27 …