Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks
TL Murphy, R Tussiwand, KM Murphy - Nature reviews immunology, 2013 - nature.com
Basic leucine zipper transcription factor ATF-like (BATF), BATF2 and BATF3 belong to the
activator protein 1 (AP-1) family of transcription factors, which regulate numerous cellular …
activator protein 1 (AP-1) family of transcription factors, which regulate numerous cellular …
Immune cells and inflammation in diabetic nephropathy
Z Zheng, F Zheng - Journal of diabetes research, 2016 - Wiley Online Library
Diabetic nephropathy (DN) is a serious complication of diabetes. At its core, DN is a
metabolic disorder which can also manifest itself in terms of local inflammation in the …
metabolic disorder which can also manifest itself in terms of local inflammation in the …
The Th17 lineage: from barrier surfaces homeostasis to autoimmunity, cancer, and HIV-1 pathogenesis
The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …
Transcriptional and epigenetic regulation of T‐helper lineage specification
SK Tripathi, R Lahesmaa - Immunological reviews, 2014 - Wiley Online Library
Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …
Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17–producing T-helper cell differentiation
Aryl hydrocarbon receptor (AHR) plays critical roles in various autoimmune diseases such
as multiple sclerosis by controlling interleukin-17 (IL-17)–producing T-helper (TH17) and …
as multiple sclerosis by controlling interleukin-17 (IL-17)–producing T-helper (TH17) and …
Evaluation of intracellular signaling downstream chimeric antigen receptors
H Karlsson, E Svensson, C Gigg, M Jarvius… - PloS one, 2015 - journals.plos.org
CD19-targeting CAR T cells have shown potency in clinical trials targeting B cell leukemia.
Although mainly second generation (2G) CARs carrying CD28 or 4-1BB have been …
Although mainly second generation (2G) CARs carrying CD28 or 4-1BB have been …
Interleukin-1β alters glutamate transmission at purkinje cell synapses in a mouse model of multiple sclerosis
G Mandolesi, A Musella, A Gentile… - Journal of …, 2013 - Soc Neuroscience
Cerebellar deficit contributes significantly to disability in multiple sclerosis (MS). Several
clinical and experimental studies have investigated the pathophysiology of cerebellar …
clinical and experimental studies have investigated the pathophysiology of cerebellar …
Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells
Background Our previous studies showed that the non-psychoactive cannabinoid,
cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin oligodendrocyte …
cannabidiol (CBD), ameliorates the clinical symptoms in mouse myelin oligodendrocyte …
mTORC1 signaling and IL‐17 expression: defining pathways and possible therapeutic targets
IL‐17 mediates immune responses against extracellular pathogens, and it is associated with
the development and pathogenesis of various autoimmune diseases. The expression of IL …
the development and pathogenesis of various autoimmune diseases. The expression of IL …
Transcription factor EGR2 controls homing and pathogenicity of TH17 cells in the central nervous system
Abstract CD4+ T helper 17 (TH17) cells protect barrier tissues but also trigger autoimmunity.
The mechanisms behind these opposing processes remain unclear. Here, we found that the …
The mechanisms behind these opposing processes remain unclear. Here, we found that the …