Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment
Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …
to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically …
From recognition to remedy: The significance of biomarkers in neurodegenerative disease pathology
C Toader, N Dobrin, FM Brehar, C Popa… - International journal of …, 2023 - mdpi.com
With the inexorable aging of the global populace, neurodegenerative diseases (NDs) like
Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) …
Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) …
Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling
Dementia is a syndrome associated with a wide range of clinical features including
progressive cognitive decline and patient inability to self-care. Due to rapidly increasing …
progressive cognitive decline and patient inability to self-care. Due to rapidly increasing …
Gut mucosal proteins and bacteriome are shaped by the saturation index of dietary lipids
The dynamics of the tripartite relationship between the host, gut bacteria and diet in the gut
is relatively unknown. An imbalance between harmful and protective gut bacteria, termed …
is relatively unknown. An imbalance between harmful and protective gut bacteria, termed …
Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer's disease with cerebrovascular disease
Background Dementia risk in women is higher than in men, but the molecular
neuropathology of this gender difference remains poorly defined. In this study, we used …
neuropathology of this gender difference remains poorly defined. In this study, we used …
Comparison of iTRAQ and SWATH in a clinical study with multiple time points
A Jylhä, J Nättinen, U Aapola, A Mikhailova, M Nykter… - Clinical Proteomics, 2018 - Springer
Background Advances in mass spectrometry have accelerated biomarker discovery in many
areas of medicine. The purpose of this study was to compare two mass spectrometry (MS) …
areas of medicine. The purpose of this study was to compare two mass spectrometry (MS) …
Role of lncRNAs in cellular aging
U Degirmenci, S Lei - Frontiers in endocrinology, 2016 - frontiersin.org
Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate
cellular processes including cellular senescence, telomere shortening, stem cell exhaustion …
cellular processes including cellular senescence, telomere shortening, stem cell exhaustion …
Deep profiling of microgram-scale proteome by tandem mass tag mass spectrometry
Tandem mass tag (TMT)-based mass spectrometry (MS) enables deep proteomic profiling of
more than 10,000 proteins in complex biological samples but requires up to 100 μg protein …
more than 10,000 proteins in complex biological samples but requires up to 100 μg protein …
Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats
C Yang, C Zheng, Y Zhuang, S Xu, J Li, C Hu - Molecular Neurobiology, 2024 - Springer
Synaptic dysfunction is considered the best neuropathological correlate of cognitive decline
in vascular dementia (VaD). However, the alterations of synaptic proteins at the …
in vascular dementia (VaD). However, the alterations of synaptic proteins at the …
Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression
There is a need to better understand meningioma oncogenesis for biomarker discovery and
development of targeted therapies. Histological or genetic criteria do not accurately predict …
development of targeted therapies. Histological or genetic criteria do not accurately predict …