Cancer prognosis remains a lottery dependent on cancer type, disease stage at diagnosis,
and personal genetics. While investment in research is at an all‐time high, new drugs are …

Modeling the heterogeneity of the tumor microenvironment (TME) in vitro is essential to
investigating fundamental cancer biology and developing novel treatment strategies that …

Because of the heterogeneity and complexity of tumor structure, cancer drugs often cannot
effectively reach the tumor, which is one of the reasons for drug resistance and treatment …

Tissue engineering faces a recurring challenge in the transformation of biomaterials into 3D
constructs that mimic the biological, chemical, and mechanical features of native tissues …

Paper-based cultures are an emerging platform for preparing 3D tissue-like structures.
Chemical gradients can be imposed upon these cultures, generating microenvironments …

This protocol describes how to build and implement a three-dimensional (3D) cell culture
system, TRACER (tissue roll for analysis of cellular environment and response), that enables …

The paper-based culture platform developed by Whitesides readily incorporates tissue-like
structures into laboratories with established workflows that rely on monolayer cultures. Cell …

Patient‐derived organoids have emerged as a useful tool to model tumour heterogeneity.
Scaling these complex culture models while enabling stratified analysis of different cellular …

During pregnancy, the placenta is critical for the regulation of maternal homeostasis and
fetal growth and development. Exposures to environmental chemicals during pregnancy can …

Paper-based cell culture platforms have emerged as a promising approach for a myriad of
biomedical applications, such as tissue engineering, disease models, cancer research …