Monitoring of minimal residual disease (MRD) has become routine clinical practice in
frontline treatment of virtually all childhood acute lymphoblastic leukemia (ALL) and in many …

Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …

B cells are critical for the production of antibodies and protective immunity to viruses. Here
we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS …

Despite the growing number of immune repertoire sequencing studies, the field still lacks
software for analysis and comprehension of this high-dimensional data. Here we report …

Amplicon-based next-generation sequencing (NGS) of immunoglobulin (IG) and T-cell
receptor (TR) gene rearrangements for clonality assessment, marker identification and …

PURPOSE Although the majority of patients with relapsed or refractory large B-cell
lymphoma respond to axicabtagene ciloleucel (axi-cel), only a minority of patients have …

Acute systemic lupus erythematosus (SLE) courses with surges of antibody-secreting cells
(ASCs) whose origin, diversity and contribution to serum autoantibodies remain unknown …

The human genome contains approximately 20 thousand protein-coding genes, but the size
of the collection of antigen receptors of the adaptive immune system that is generated by the …

Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing
antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of …

Next-generation DNA sequencing promises to revolutionize clinical medicine and basic
research. However, while this technology has the capacity to generate hundreds of billions …